If you are attempting to download and install the Prolific USB-to-Serial driver in 2021 or later, you likely encountered the (This device cannot start). This is not a malfunction of your hardware, but a software conflict intentionally introduced by Prolific.
To ensure this specific driver version works, you must manually prevent Windows from automatically updating to a non-functional newer version. Download the Driver: prolific usb to serial comm port version 32 00 download 2021