That being said, some publicly available information (mostly from 2014) mentions a few cracks and workarounds for Rocksmith 2014. Keep in mind that these may not be reliable or safe:
: A "no-CD crack" refers to a modification or patch that allows a game to run without the original CD or DVD inserted into the computer's disc drive. This is often sought after by users who want to play the game without having to switch discs or for those who don't have a disc drive. rocksmith 2014 no cd crack verified